Here are some of the most prominent cases. Natalee Holloway, center, vanished in 2005. While a judge declared her legally dead, investigators still have not found her body. (File)Holloway mysteriously vanished without a trace during a 2005 high school graduation trip to the paradise island of Aruba. Her puzzling disappearance sparked a worldwide media frenzy and a massive search of the island. Though an Alabama judge declared her legally dead in 2012, Natalee's body was never found, and to this day, it is still a mystery what happened. But one detail that has never swayed is the central suspect involved: Joran van der Sloot. He and Holloway met at a hotel-casino that summer night, and witnesses say they saw the pair leave a nightclub together. But what transpired next has been in question ever since. Lauren Spierer, right, a 20-year-old student at Indiana University, disappeared June 3, 2011. Police say Spierer was last seen walking alone and barefoot to her apartment complex in downtown Bloomington, Ind. Dulce Maria Alvarez vanished two years ago; she was last seen at a park in New Jersey.
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